Platelet activation responses. Washed platelets from Cbs^+/+ or Cbs^+/– mice fed either the control or HM/LF diets were either left unstimulated or activated by thrombin (0.5 U/mL) or thrombin plus convulxin (250 ng/mL; n = 4-6 in each group). (A) Surface expression of P-selectin. (B) Annexin V binding. (C) Coated platelets, defined as the population of activated platelets with high surface levels of fibrinogen and low PE-JON/A binding.²¹  (D) Thrombin generation in a platelet procoagulant activity assay. Values are mean ± SEM.