PKC412 and metabolites. (A) CGP6221 and CGP52421 are generated from PKC412 via P450 liver enzyme metabolism.17 (B) Trough plasma concentrations of PKC412 (•), CGP62221 (□), and CGP52421 (○) averaged for patients treated with 75 mg PKC412 orally every 8 hours. Error bars represent standard deviations.