Anti-Sm antibody ASC production in autoimmune mice. (A) Serum anti-Sm levels are shown for mice 2 to 4 months of age. (B) The number ± SEM of anti-Sm ASCs in the bone marrow (BM), spleen, MLN, and LP as determined by ELISpot assay is shown (**P < .01 in comparison with 2-12H mice; n ≥ 3).