Figure 4.
Figure 4. Homing of TCR-transduced T cells to self-antigen–expressing peripheral tissue. RIP-OVAhi mice received 1 × 105 F5 (left) or OT-I (right) transduced T cells followed by inflova infection. Pancreatic islet infiltration by CD8+ cells and islet integrity were determined on day 7. Immunohistochemical analysis for ovalbumin (top) or CD8 (bottom) is shown. Original magnification, ×20.

Homing of TCR-transduced T cells to self-antigen–expressing peripheral tissue. RIP-OVAhi mice received 1 × 105 F5 (left) or OT-I (right) transduced T cells followed by inflova infection. Pancreatic islet infiltration by CD8+ cells and islet integrity were determined on day 7. Immunohistochemical analysis for ovalbumin (top) or CD8 (bottom) is shown. Original magnification, ×20.

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