Effect of C/EBPα activation on survival of mice injected with 32D-BCR/ABL cells and on in vivo differentiation of 32D-BCR/ABL cells. (A) Survival of mice (n = 10) injected with p42 C/EBPα-ER^TAM 32D-BCR/ABL cells (10⁵/mouse) and left untreated or treated with 4-HT (1 mg/d for 15 consecutive days). (B) Survival of mice (n = 7) injected with K298E C/EBPα-ER^TAM 32D-BCR/ABL cells (10⁵/mouse) and left untreated or treated with 4-HT (1 mg/d for 15 consecutive days). (C) Gr-1 levels in GFP-positive 32D-BCR/ABL cells expressing p42 C/EBPα-ER^TAM or K298E C/EBPα-ER^TAM and treated with 4-HT.