Figure 6.
Figure 6. Effect of C/EBPα activation on mice injected with 32D-BCR/ABLT315I cells. (A) Survival of mice injected with Δ177-191 C/EBPα-ERTAM 32D-BCR/ABLT315I cells (105 cells/mouse) and treated 2 days later with vehicle only or with 4-HT (1 mg/d for 15 consecutive days). (B) Methylcellulose colony formation assays, (C) Gr-1 immunostaining, and (D) DNA content of GFP-positive cells isolated from bone marrow and spleen of mice injected with Δ177-191 C/EBPα-ERTAM 32D-BCR/ABL cells (105 cells/mouse) and treated 14 days later with vehicle only or with 4-HT (1 mg/12 hours, for 3 injections). Colony number values represent mean ± SD of 3 different experiments.

Effect of C/EBPα activation on mice injected with 32D-BCR/ABLT315Icells. (A) Survival of mice injected with Δ177-191 C/EBPα-ERTAM 32D-BCR/ABLT315I cells (105 cells/mouse) and treated 2 days later with vehicle only or with 4-HT (1 mg/d for 15 consecutive days). (B) Methylcellulose colony formation assays, (C) Gr-1 immunostaining, and (D) DNA content of GFP-positive cells isolated from bone marrow and spleen of mice injected with Δ177-191 C/EBPα-ERTAM 32D-BCR/ABL cells (105 cells/mouse) and treated 14 days later with vehicle only or with 4-HT (1 mg/12 hours, for 3 injections). Colony number values represent mean ± SD of 3 different experiments.

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