Figure 7.
Effect of dominant-negative peptide on B16-F1 melanoma tumor growth. (A) B16 tumor cell growth (mm3) in nude mice (control), in the presence of peptide A1, or mutant peptide A1 over time using calipers (left panel). Tumors were excised at 14 days and tumor volume was determined (*P < .001 versus control). Values represent means ± SE; n = 6 in each group. (B) Immunofluorescence staining for CD31, in tumors grown as described in “Mouse tumor models,” and assessment of vessel density (*P < .001 compared with control).
