Transgene facilitation of hematopoietic regulators. (A) The proposed concept involves stress-induced switch from production of AChE-S to the -R variant, resulting in hematopoietic progenitor cell expansion toward the megakaryocyte lineage and increased platelet counts. (B) Human (h) AChE-R DNA construct inserted into the FVB/N mouse genome. hAChE-R cDNA-derived 100-base pair product was successfully amplified in bone marrow DNA of TgR but not TgS or FVB/N mice (n = 12, left arrow). A mouse actin product (130 base pair, right arrow) appeared in all 3 tested lines, FVB/N, TgR, and TgS. (C) Transgene-induced changes in IL-6 and AChE activity (± SEM; ^*P < .01, Student t test).