Clinical course of 6 long-term surviving CLAD dogs following gene therapy. The clinical course of the 6 long-term CLAD survivors treated with gene therapy is shown prior to and following infusion of gene-corrected cells. The line and arrow indicate the period of follow-up for each dog. Episodes of fever (≥ 102.4°F) necessitating a more aggressive treatment (increased antibiotics/fluids) are shown by the vertical lines. The shaded boxes indicate periods during which the animal was in intensive care. The appearance of an episode of HOD (lameness/joint swelling/leg pain) or CMO (bony jaw/cranial swelling/soreness) is indicated by the closed diamonds. The day of infusion (day 0) is indicated. Attainment of a CD18⁺ ANC level of 100 ± 5 cells/μL is indicated by the inverted pyramid. Time in days in relationship to the infusion is shown on the x-axis in the panel.