Identification of TAL1 direct target genes by ChIP on chip in Jurkat cells. (A) Scatterplot representation of a genomic microarray (Hu13K) hybridization with a chromatin immunoprecipitation performed using a TAL1 antibody. The x-axis indicates the log intensity of the fluorescence of the control DNA, labeled with Cy3, while the y-axis represents the log fluorescence intensity of the TAL1 chromatin immunoprecipitates (TAL1-IP) labeled with Cy5. Each dot represents a promoter region from the Hu13K arrays. The colored lines represent the P values calculated by the error model applied to the fluorescence data. (B) Functional classification of the 71 TAL1 targets according to Gene Ontology and/or National Center for Biotechnology Information (NCBI) data for the identified genes. Note the broad spectrum of functional categories of genes regulated by TAL1.