PFS curves based on cytogenetics and ZAP-70 expression within cytogenetic subsets. (A) Patients with B-CLL with a normal karyotype showed a longer PFS (P = .004) as compared with high-risk genetic aberrations. (11q–,17p–, and +13). Black line indicates normal; dashed line, poor; and gray line, del 13q. (B-C) ZAP-70 protein overexpression distinguished patients at worse prognosis both within normal karyotype (P < .001) and within the poor-risk B-CLL subset (P = .02). Black line indicates ZAP-70 < 20%; gray line, ZAP-70 > 20%.