PFS curves in discordant patients (ZAP-70⁺CD38^–/ZAP-70^–CD38⁺and ZAP-70⁺M/ZAP-70^–UM) and in ZAP-70^–patients by sCD23 levels. (A-B) Interestingly, ZAP-70^– either CD38⁺ or UM patients showed a longer PFS in comparison with ZAP-70⁺ either CD38^– or M patients (P < .001 and P = .002, respectively). In panel A, the gray line indicates ZAP-70⁺CD38^–; the black line, ZAP-70^–CD38⁺. In panel B, the gray line indicates ZAP-70⁺ M; the black line, ZAP-70^– UM. (C) Levels lower than 70 U/mL of sCD23 identified patients with a longer PFS within the ZAP-70^– subset (P < .001). Black line indicates sCD23 < 70 U/mL; gray line, sCD23 > 70 U/mL.