Progression-free survival (PFS) curves based on ZAP-70, CD38 expression, and soluble CD23 (sCD23) levels. (A) Kaplan-Meier plot comparing progression-free survival based on the detection of greater than 20% or lower than 20% ZAP-70⁺ B cells. Lower than 20% ZAP-70⁺ patients experienced a longer PFS (P < .001). Black line indicates ZAP-70 < 20%; gray line, ZAP-70 > 20%. (B) Equally, patients with B-CLL with CD38⁺ lower than 30% showed a significantly longer PFS (P < .001). Black line indicates CD38 < 30%; gray line, CD38 > 30%. (C) sCD23 levels lower than 70 U/mL characterized patients with a longer PFS (P < .001). Black line indicates sCD23 < 70 U/mL; gray line, sCD23 > 70 U/mL.