Survival and change in CSF protein with DepoCyt versus standard alternating methotrexate and cytarabine. (A) A Kaplan-Meier curve demonstrating the overall survival of individuals with ARL and meningeal disease, treated with either DepoCyt or alternating intrathecal installations of methotrexate and cytarabine. (B) A comparison of the rate of fall of CSF protein from the first intrathecal installation to 1 month. The median with the standard error of the mean is shown.