Figure 5.
Model depicting the pathways linking activated Notch3 with the induction of cyclin D1. Notch3-IC has been shown to activate the pTα promoter, thus promoting activation of pre-TCR signaling that in turn results in ERK1/2 activation. Signaling through the IL-2/IL-2R pathway acts to increases Tal1 expression. The induction of pTal1/Sp1 complex through a pre-TCR/ERK1/2-dependent pathway activates cyclin D1 expression.

Model depicting the pathways linking activated Notch3 with the induction of cyclin D1. Notch3-IC has been shown to activate the pTα promoter, thus promoting activation of pre-TCR signaling that in turn results in ERK1/2 activation. Signaling through the IL-2/IL-2R pathway acts to increases Tal1 expression. The induction of pTal1/Sp1 complex through a pre-TCR/ERK1/2-dependent pathway activates cyclin D1 expression.

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