Figure 4.
Figure 4. Viral RNA levels in plasma and lymph nodes. (A) Virus levels in plasma of the macaques treated with ART alone (top panel) or ART plus anti–CTLA-4 (bottom panel). (B) SIVmac251 RNA quantified on 1 μg total RNA extracted from macaque lymph nodes before initiation of ART (pre-ART), and after 6 weeks of treatment (ART) and MDX-010 (ART and anti–CTLA-4). Horizontal bars within boxes correspond to the median; box limits correspond to the 25th and 75th percentiles; and vertical lines extend to the 10th and 90th percentiles. (C) Changes in SIVmac251 RNA induced by ART and ART plus MDX-010 (ART and anti–CTLA-4) after 6 weeks of treatment. Mean values plus standard error are shown. (D-E) CD4+ (D) and CD8+ (E) absolute counts per cubic millimeter in blood of the macaques over time.

Viral RNA levels in plasma and lymph nodes. (A) Virus levels in plasma of the macaques treated with ART alone (top panel) or ART plus anti–CTLA-4 (bottom panel). (B) SIVmac251 RNA quantified on 1 μg total RNA extracted from macaque lymph nodes before initiation of ART (pre-ART), and after 6 weeks of treatment (ART) and MDX-010 (ART and anti–CTLA-4). Horizontal bars within boxes correspond to the median; box limits correspond to the 25th and 75th percentiles; and vertical lines extend to the 10th and 90th percentiles. (C) Changes in SIVmac251 RNA induced by ART and ART plus MDX-010 (ART and anti–CTLA-4) after 6 weeks of treatment. Mean values plus standard error are shown. (D-E) CD4+ (D) and CD8+ (E) absolute counts per cubic millimeter in blood of the macaques over time.

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