Median bleeding-free days following infusion of rFVIII or PEGLip rFVIII. OD indicates bleeding episode followed by on demand treatment; Proph 1, standard rFVIII prophylaxis infusion; and PEGLip rFVIII, PEGylated liposome–reconstituted Kogenate FS prophylaxis infusion. OD6 and OD9 were shorter than prior intervals, since patients were scheduled for the prophylactic infusion in a nonbleeding state following a 4-day wash-out period.