Severe malarial anemia at low parasite burden in rodent malaria infections. (A) Representative data from 3 infected semi-immune BALB/c mice showing parasitemia (•) and Hb levels (▴) following infection with 10⁴P berghei. (B) Parasitemia (•) and Hb levels (▴) of naive inoculum control BALB/c mice. (C) Lack of correlation between peak parasitemia and minimum Hb levels in infected semi-immune mice. (D) Parasitemia (•), reticulocyte levels (○), and Hb (▴) of semi-immune mice normalized to the day of patency. (E) Mean parasitemias (•), reticulocyte levels (○), and Hb (▴) in naive adult rats infected with P berghei. n = 14 ± SEM for immune mice; n = 6 ± SEM for naive mice and naive rats.