Figure 3.
Figure 3. Lack of CTLA-4 expression does not enhance antitumor efficacy of adoptively transferred self/tumor-reactive CD8+ T cells. (A) C57BL/6 mice bearing 10-day-old established subcutaneous B16 tumors were left untreated as control or received adoptive transfer of 1 × 106 cultured pmel-1 or pmel-1 CTLA-4–/– T cells in conjunction with rFPhgp100 vaccination and exogenous rhIL-2 (36 μg per dose). (B) Sublethally irradiated mice (5 Gy) received 1 × 106 cultured pmel-1 CTLA+/+ or pmel-1 CTLA-4–/– T cells. The following day, mice were challenged with 5 × 105 B16 cells. Tumor area results are the mean of measurements from 5 mice per group (± SEM).

Lack of CTLA-4 expression does not enhance antitumor efficacy of adoptively transferred self/tumor-reactive CD8+T cells. (A) C57BL/6 mice bearing 10-day-old established subcutaneous B16 tumors were left untreated as control or received adoptive transfer of 1 × 106 cultured pmel-1 or pmel-1 CTLA-4–/– T cells in conjunction with rFPhgp100 vaccination and exogenous rhIL-2 (36 μg per dose). (B) Sublethally irradiated mice (5 Gy) received 1 × 106 cultured pmel-1 CTLA+/+ or pmel-1 CTLA-4–/– T cells. The following day, mice were challenged with 5 × 105 B16 cells. Tumor area results are the mean of measurements from 5 mice per group (± SEM).

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