Figure 3.
Figure 3. Greater splenomegaly in P210/STAT5A–/– CML mice. The average spleen weight (left panel) and peripheral WBC count (right panel) at autopsy is depicted by bar graph according to the STAT5A genotype of the leukemia cells. The difference in splenomegaly between P210/STAT5A-null (n = 4) and P210/STAT5A wild-type (n = 12) CML mice was statistically significant (P = .046), but the difference in WBC counts (n = 4 and n = 8, respectively) was not (P = .38). The error bars represent the standard error. For comparison, the average spleen weight of normal mice was 70 mg, and the average WBC counts of nonleukemic STAT5A–/– and STAT5A+/+ mice was 4.6 × 109/L (4600/μL) and 5.5 × 109/L (5500/μL), respectively.

Greater splenomegaly in P210/STAT5A–/– CML mice. The average spleen weight (left panel) and peripheral WBC count (right panel) at autopsy is depicted by bar graph according to the STAT5A genotype of the leukemia cells. The difference in splenomegaly between P210/STAT5A-null (n = 4) and P210/STAT5A wild-type (n = 12) CML mice was statistically significant (P = .046), but the difference in WBC counts (n = 4 and n = 8, respectively) was not (P = .38). The error bars represent the standard error. For comparison, the average spleen weight of normal mice was 70 mg, and the average WBC counts of nonleukemic STAT5A–/– and STAT5A+/+ mice was 4.6 × 109/L (4600/μL) and 5.5 × 109/L (5500/μL), respectively.

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