Figure 3.
Figure 3. MEK blockade causes growth inhibition of leukemic cells and modulates p21Waf1/CIP1 expression in AML blasts. (A) Leukemic blasts from patients were cultured in the presence of PD 184352, ATO, or both for 48 hours and were stained for DNA content (*P < .05; **P < .001 vs control vehicle; Dunnett test). Values are mean ± SD. (B) AML blasts were cultured for 48 hours in the presence of PD 184352, ATO, or both and were subjected to Western blot analysis with mouse monoclonal anti-p21Waf1/Cip1 (DCS60).

MEK blockade causes growth inhibition of leukemic cells and modulates p21Waf1/CIP1 expression in AML blasts. (A) Leukemic blasts from patients were cultured in the presence of PD 184352, ATO, or both for 48 hours and were stained for DNA content (*P < .05; **P < .001 vs control vehicle; Dunnett test). Values are mean ± SD. (B) AML blasts were cultured for 48 hours in the presence of PD 184352, ATO, or both and were subjected to Western blot analysis with mouse monoclonal anti-p21Waf1/Cip1 (DCS60).

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal