BMT from a NIMA-exposed donor reduces acute GVHD in an antigen-specific fashion. Lethally irradiated (13 Gy) B6D2F1 mice received transplants with 5 × 10⁶ TCD BM from control B6 mice together with 2 × 10⁶ T cells from either a NIMA-exposed B6 or control B6 donor. (A) Survivals of recipients of syngeneic BMT (, n = 15), allogeneic BMT from a control donor (○, n = 25), and allogeneic BMT from a NIMA-exposed B6 (•,n = 25) are shown. Data from 5 similar experiments were combined. (B) Clinical scores of these recipients are shown as the mean ± SE. (C) Forty days after BMT, thymuses were harvested and DP cells were enumerated. Data are shown as mean ± SD. (D) Survival rates of third-party B6C3F1 (H-2^b/k) mice receiving 2 × 10⁶ T cells from an H-2^d-NIMA–exposed B6 donor along with 5 × 10⁶ TCD BM from a control B6 mouse. ^*P < .05, ^**P < .005 versus controls.