PET and PET/CT images of 2 patients with stage III Hodgkin lymphoma. Panels A-B and E-F are PET/CT images with CT, PET, and fusion images from left to right. Panels C-D are PET images. Patient A initially had involvement of cervical regions, left axilla, mediastinum, and the para-aortic glands in retroperitoneum (A, brown arrows). After 2 cycles of chemotherapy, CT still showed cervical and mediastinal swelling, while PET showed only physiologic uptake. Patient A is now in the fourth year of complete remission. Patient B initially had involvement of the left base of the neck, left axilla, mediastinum, and the spleen (C, brown arrows). After 2 cycles of chemotherapy (D-F), there was still some pathologic FDG uptake in the mediastinum (red arrows) and upper abdomen (pink arrows). The patient was considered in remission after treatment ended but later relapsed in the mediastinum.