TCR and CD16 mediated target-cell recognition by HLA-A*0201/CMV-pp65^N9V–specific C31DO8 T-cell clone. Nontransduced control and CD16/γ–transduced C31DO8 T-cell clones were tested (A) against an HLA-A*0201-CD20⁺ autologous BLCL in the presence of the increasing concentrations of N9V peptide (to test TCR-dependent cytolytic activity) and (B) in the presence of a humanized anti-CD20 mAb (rituximab) (to assess ADCC activity). Both tests were performed in the same ⁵¹Cr-release assay. Results are expressed as percent of specific lysis (effector-to-target ratio = 30:1, mean of triplicate). In A and B, • indicates nontransduced clone; ▪, transduced clone.