Individual genome profiles of amplification at 6p, 7p, and 14q. Although there were only 2 lymphoma-type cases with high copy number gains, 3 regions are shown because they contained genes implicated in lymphomagenesis. No high copy number gains were found in acute-type cases. (A) Individual genome profiles of high copy number gains at 7p22.2 for 2 patients (D1706 and D1707). Horizontal lines indicate the megabase (Mb) from the 7p telomere to the centromere, and vertical lines show the log₂ ratio. Spots are ordered contiguously from the p telomere to the centromere, with an average resolution of 1.3 Mb. The threshold for gain and loss was defined as a log₂ ratio of +0.2 and –0.2, respectively. The arrow above each graph represents the highest peak at 7p22.2. RP11-498D18 located in the peak contains CARMA1. (B) Individual genome profiles of high copy number gains at 14q32 for 2 patients (D1678 and D1711). Spots are ordered contiguously from the 14q centromere to the 14q telomere. The arrow above each graph represents the highest peak at 14q32. RP11-1127D7 located in the peak is 0.3 Mb telomeric to BCL11B. (C) Individual genome profiles of high copy number gains at 6p25 for 2 patients (D1697 and D1709). Spots are ordered contiguously from the 6p telomere to the 6p centromere. The arrow above each graph represents the highest peak at 6p25. RP11-233K4 located in the peak contains IRF4. Based on information from the Ensembl Genome Data Resources of the Sanger Center Institute and NCBI. Vertical dotted lines represent the boundary between 5q and 6q telomeres.