Imatinib decreases lacunae formation and the number of lacunae containing OCs in BALB/c mice. Adult Balb/c mice were administered 75 mg/kg imatinib per day for 8 weeks. Parrafin-embedded sections of mouse femur were enumerated for the number of lacunae over 10 fields of view (Lacunae/10HPF), the number of lacunae containing OCs (Lacunae + OC), the number of lacunae without OCs (Lacunae - OC) and the number of OCs not present in lacunae (OC - Lacunae) in control (▦) and imatinib treated (□) mice. Results are representative of averaged data from 5 mice. *P < .05 (relative to the control). Error bars represent the SEM.