Imatinib decreases RANK expression by OCs. CD14⁺ cells from healthy donors were used to establish OC assays to examine the effect of imatinib on RANK expression on days 0, 1 (▪),7(□), and 14 (▦) of culture. A dose-dependent decrease in RANK expression by OCs was observed in the presence of imatinib across 14 days of culture. Results are representative of 3 individual experiments using different donors. *P < .01 (relative to the 0 μM control for each time point). Error bars represent the SEM.