IL-17 promotes endothelial cord formation.

(A) Factor VIII–stained microvessels developed by medium alone. (B) Factor VIII–stained microvessels developed by 50 ng/mL IL-17. (C) Factor VIII–stained microvessels developed by 10 ng/mL VEGF. (D) Factor VIII–stained microvessels developed by 100 μM suramin. (E) IL-17 (1-500 ng/mL) markedly enhanced the development of microvessel-like structures. VEGF (10 ng/mL) also promoted the microvessel formation. Suramin significantly inhibited the development of microvasculature. Bars represent the mean number of pixels ± SD (n = 6). The result is a representative of 2 independent experiments.