Fig. 7.
Fig. 7. Proposed model of the regulation of IRBC adhesion to CD36 on HDMECs under flow conditions. / The initial attachment of IRBCs to CD36 (step 1) leads to an Src-family kinase–dependent intracellular signal (step 2) that is responsible for increasing subsequent IRBC adhesion to CD36 by means of an ecto-ALP (step 3) that dephosphorylates and hence increases the binding affinity of CD36 for IRBCs (step 4).

Proposed model of the regulation of IRBC adhesion to CD36 on HDMECs under flow conditions.

The initial attachment of IRBCs to CD36 (step 1) leads to an Src-family kinase–dependent intracellular signal (step 2) that is responsible for increasing subsequent IRBC adhesion to CD36 by means of an ecto-ALP (step 3) that dephosphorylates and hence increases the binding affinity of CD36 for IRBCs (step 4).

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