Fig. 2.
The effect of the Src-family kinase inhibitor PP1 on IRBC cytoadherence under flow conditions.
The effects are shown for rolling IRBCs (A) and adherent IRBCs (B-E). Confluent HDMEC monolayers were pretreated with 1, 5, or 10 μM PP1 or 10 μM PP3 (the inactive analog) for 30 minutes at 37°C. IRBCs were infused at 1 dyne/cm2 (n = 3 for 1 and 5 μM PP1 and 10 μM PP3; n = 6 for 10 μM PP1). Values are presented as means ± SEM. *P < .05, ***P < .001.
