Fig. 5.
Pre-existing humoral immune response against human apo A-I is not abrogated by AdAT4 gene transfer.
(A) Human apo A-I expression after gene transfer with 5 × 108 pfu ofAdAT4 (▪) in mice subcutaneously immunized with human apo A-I protein 4 months before gene transfer. (B) Inverse of the titer of antibodies against human apo A-I after gene transfer with 5 × 108 pfu AdAT4 in mice subcutaneously immunized with human apo A-I protein 4 months before gene transfer (▪). Day 0 is the time of gene transfer. Titers of antibodies were unchanged after gene transfer compared with titers in the preceding months, which are not shown.
