CMV-specific CD8⁺ T cells in primary CMV infection are cytotoxic irrespective of their phenotype.

All plots gated on total CD8⁺ T cells, time defined as days after first positive PCR (day 0); day 31, peak of CMV-specific CD8⁺ T cell frequency; day 279, time point during latency. (A) x-axis log fluorescence CMV-tetramer, y-axis log fluorescence Ki-67; (B) x-axis log fluorescence CMV-tetramer, y-axis log fluorescence granzyme B; (C) x-axis log fluorescence CMV-tetramer, y-axis log fluorescence perforin. Quadrant percentages depicted as percentages of total CD8⁺ cells.