Ribbon representation of the human VWF A1 domain and location of the mutated residues.

The tridimensional structure front view of the A1 domain, based on the 3-dimensional coordinates by Celikel et al,12 is shown with the spatial distribution of all 9 mutated residues, displayed in ball-and-stick representation. Critical secondary structural elements were colored for clarity. For space considerations, single-letter codes were used for amino acids. The helix α3 is shown in red; strands β3 and β4 are shown in yellow; β-turn sequences are displayed in violet. Pictures were created with RasMol v2.6 (Glaxo Research and Development, London, United Kingdom).