Changes in renal vascular permeability in rats subjected to renal ischemia/reperfusion and effects of antithrombin (AT) and other materials on renal ischemia/reperfusion (I/R)–induced increases in renal vascular permeability.

(A) Renal vascular permeability was evaluated just before ischemia (Pre) and at indicated time points after reperfusion. (B) Renal vascular permeability was evaluated 6 hours after reperfusion in rats subjected to renal ischemia/reperfusion. mAT indicates Trp49-modified AT. Data are expressed as mean ± SD values of 6 animals. Open circle indicates sham-operated group; filled circle, vehicle-treated group. *P < .01 versus sham-operated group; †P < .05 versus vehicle-treated group; §P < .01 versus AT-treated group; ¶P < .01 versus IM-treated group.