Effect of antithrombin (AT), DEGR-F.Xa, and Trp49-modified AT on renal cortical blood flow during ischemia/reperfusion (I/R) injury in rats.

Renal cortical blood flow was measured from 30 minutes before ischemia until 3 hours after reperfusion. Data are expressed as means ± SDs of 5 experiments. Open circle indicates vehicle-treated group; filled circle, AT-treated group; open triangle, DEGR-F.Xa–treated group; filled triangle, Trp49-modified AT-treated group. *P < .05 versus vehicle-treated group.