Fig. 6.
Effect of caspase inhibitors on apoptosis in B-CLL cells following exposure to EB1089 (1 × 10−8 M) for 48 hours.
Apoptosis was quantified using changes in forward and side light scatter. Results are the mean (± SD) of 3 separate experiments. The pancaspase inhibitor, Z-VAD-FMK, and the caspase-9 inhibitor, Z-LEHD-FMK, both demonstrated the ability to abrogate the apoptotic effects of EB1089.
