Caspase-3 activation in B-CLL cells following exposure to EB1089 for 48 hours.

Caspase-3 activity was determined by using a specific active caspase-3-RPE-labeled antibody as described in “Patients, materials, and methods.” The increase in caspase-3 activation (M2) was concentration dependent and was correlated with an increase in apoptotic cell death. Percentages indicate apoptotic cell death at each concentration of EB1089.