Fig. 5.
CD19-specific CD8+ T cells produce cytokines in response to CD19+ B-ALL and lymphoma stimulator cells.
T cells (106) from a CD8+ CTL clone were cocultured with mitomycin-treated CD19+ B-ALL and lymphoma lines SUP-B15, LCL, RS4, Daudi, or the CD19− line K562. After 7 days, secretion of the cytokines GM-CSF (A), TNF-α (B), and IFN-γ (C) were quantified from conditioned supernatant by an ELISA.
