Pim-2 is overexpressed in leukemic bone marrow.

Bone marrow from 84 patients with AML was analyzed for Pim-2 expression by real time RT-PCR and compared with healthy bone marrow. Box plots are shown for the relative expression levels of Pim-2 normalized for GAPDH in Flt3-ITD positive, Flt3-ITD negative AML samples, and healthy bone marrow. The difference of expression between leukemic samples and healthy bone is statistically significant (P < .05, Mann-Whitney U test).