Fig. 5.
Fig. 5. Effect of VEGFR-1/Fc or anti–VEGFR-1 MoAb on Mk polyploidization. / Cells were grown in the presence of TPO alone (▪), or combined with either 100 ng/mL VEGFR-1/Fc (░) (A) or 2 μg/mL neutralizing anti–VEGFR-1 MoAb (■) (B). Morphologic evaluation of nuclear lobe number was performed at day 8 and day 12 of culture. Mean ± SEM values of 3 independent experiments. *P < .05; **P < .01.

Effect of VEGFR-1/Fc or anti–VEGFR-1 MoAb on Mk polyploidization.

Cells were grown in the presence of TPO alone (▪), or combined with either 100 ng/mL VEGFR-1/Fc (░) (A) or 2 μg/mL neutralizing anti–VEGFR-1 MoAb (■) (B). Morphologic evaluation of nuclear lobe number was performed at day 8 and day 12 of culture. Mean ± SEM values of 3 independent experiments. *P < .05; **P < .01.

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