Fig. 2.
Fig. 2. In vitro effects of ICA-17043 on human and mouse RBCs. / Inhibition of 86Rb efflux from (A) human and (B) mouse RBCs as a function of ICA-17043 concentration. Average normalized efflux values are plotted (●, ± SD) (n = 4). The curve through the data represents a fit to a simple logistic function with (A) human blood giving an IC50 of 11 ± 2 nM and (B) mouse blood giving an IC50 of 50 ± 6 nM.

In vitro effects of ICA-17043 on human and mouse RBCs.

Inhibition of 86Rb efflux from (A) human and (B) mouse RBCs as a function of ICA-17043 concentration. Average normalized efflux values are plotted (●, ± SD) (n = 4). The curve through the data represents a fit to a simple logistic function with (A) human blood giving an IC50 of 11 ± 2 nM and (B) mouse blood giving an IC50 of 50 ± 6 nM.

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