Conservation of the C/EBP, GATA-1, and PU.1 binding sites in the human and murine MBP-P2 promoter regions.

Genomic DNA sequences for the human and murine MBP promoter regions (GenBank accession numbers M34462 and L46768, respectively) were aligned using the Align X feature of the Vector NTI 6.0 software program (Informax, Bethesda, MD). Nucleotide numbers are indicated in parentheses. Previously characterized binding sites for C/EBP and GATA-1 are shaded.30,41 The putative TATA box and transcription start site (arrow) are indicated. Conserved core consensus sequences 1 and 2 for PU.1 (GGAA) are shaded. Gaps in the alignment are denoted by −. Conserved nucleotides are indicated by the consensus sequence.