FGFR3 expression and clinical significance in t(4;14)+ MM patients.
(A) RT-PCR detection of FGFR3 expression in 11 t(4;14)+patients (the same patients and order as represented in Figure 2A-B. Lane B, H2O control. (B) Kaplan-Meier plot of survival for t(4;14) positive patients with respect to FGFR3 expression. Solid line represents the 177 t(4;14)− patients; dotted line represents the 23 t(4;14)+ patients expressing FGFR3; dashed line represents the 8 t(4;14)+ patients who do not express FGFR3. The difference in survival between t(4;14)+FGFR3 nonexpressors and t(4;14)− patients was statistically significant (P = .003). (C) Kaplan-Meier plot of survival for FGFR3-expressing patients versus nonexpressing patients. Solid line represents the 185 FGFR3 nonexpressors; dotted line represents the 23 FGFR3 expressors in the cohort (P = .11).
