Anti-CD45–mediated reduction of total white blood cells (WBCs) and neutrophils in the peripheral blood.

(A) The numbers of WBCs in the peripheral blood of mice treated with MAb (1 μg/g body weight) daily from day 0 to day 4 were counted manually and are reported as mean (± SD) percentages of change from baseline values (♦). Results for neutrophils (▪) were determined in a similar manner. Six mice were studied in each group. (B) The proportions of B cells, T cells, and NK cells were determined before and at multiple time points after Ab infusion. ░ indicates B220; ▪, CD3; and ■, NK1.1.