Effect of fucose administration on circulating neutrophil counts in the LADII patient.

Fucose therapy was initiated on day 0 (arrow). The dose of L-fucose was sharply reduced on day 36 (to 580 mg/kg per day) in response to therapy-induced neutropenia (*). Neutrophil counts were determined using an automated cell counter. The gray area marks the limits of normal absolute neutrophil counts for 1 year of age.