Regression of LMP1-expressing tumors in HLA A2/K^b mice following therapeutic immunization with Vacc.polyLMP.

HLA A2/K^b mice were challenged with 10⁷EL4-A2/K^b-LMP1 tumor cells. Twelve days after the challenge, when the tumor size was approximately 0.4 cm in diameter, these mice were immunized with either Vacc.polyLMP (▴) or Vacc.TK⁻ (▪). The therapeutic efficacy of the LMP polyepitope vaccine was assessed by regular monitoring of tumor regression. Any mice showing tumor size larger than 1.0 cm in diameter were killed according to the guidelines of the ethics committee. Data are presented as percentage of mice surviving after immunization with Vacc.polyLMP or Vacc.TK⁻.