Activation of LMP1 epitope-specific CTL lines from HLA A2/K^b mice immunized with Vacc.ployLMP.

CTL reactivity specific for LMP epitopes (YLQ, YLL, LLL, LLV, and TLL) was assessed in splenocytes of Vacc.polyLMP immunized mice following primary (1°) and secondary (2°) stimulation with indicated peptide epitope sensitized LPS blasts. These T-cell lines were used as effectors against EL4 A2/K^b cells sensitized with the same peptide (▪) or no peptide (░). Mean lysis values (±SE) for each group of mice are presented. A minimum of 6 animals was assessed for each epitope.