Fig. 9.
CVX-induced platelet aggregation is mediated by ADP-dependent and -independent components.
Aggregation traces from wild-type (wt, A-B) or Gαi2−/− (C) murine platelets treated with either control buffer (A,C) or the ADP receptor antagonists 2-MeSAMP (50 μM) and A3P5P (100 μM; B; gray arrows) for 1 minute and then stimulated with 250 ng/mL CVX (white arrows). These results were confirmed in 3 separate experiments.
