Fig. 4.
Fig. 4. Histochemical analysis of human vastus lateralis muscle and vector transduction. / (A-B) Immunohistochemical stain for fast-twitch (A) and slow-twitch (B) isoforms of myosin. (C-D) Simultaneous immunofluorescence stain for slow-twitch myosin (C) and HSPG (D) indicates cytoplasmic HSPG stain in slow-twitch muscle fibers. (E-F) Colocalization of F.IX transgene expression (E) and slow-twitch muscle fibers (F) on serial sections of biopsy from subject G, 2 months after vector administration. Original magnification × 100 for panels A-F.

Histochemical analysis of human vastus lateralis muscle and vector transduction.

(A-B) Immunohistochemical stain for fast-twitch (A) and slow-twitch (B) isoforms of myosin. (C-D) Simultaneous immunofluorescence stain for slow-twitch myosin (C) and HSPG (D) indicates cytoplasmic HSPG stain in slow-twitch muscle fibers. (E-F) Colocalization of F.IX transgene expression (E) and slow-twitch muscle fibers (F) on serial sections of biopsy from subject G, 2 months after vector administration. Original magnification × 100 for panels A-F.

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