Fig. 7.
Fig. 7. Toxicity analysis of HC-Ad vectors. / AST (black bars) and ALT (gray bars) levels (A) in plasma from FVIIIKO-SCID mice injected intravenously with 5 × 109 IU Ad-AAT-cFVIII, Ad-AAT-hFVIII, and Ad-Apo-cFVIII. Alternatively, 5 × 109 IU Ad-AAT-cFVIII was injected intravenously into FVIIIKO mice. (A) Platelet counts (B) and IL-6 levels (C) in plasma from FVIIIKO-SCID mice intravenously injected with 5 × 109 IU Ad-AAT-cFVIII, Ad-AAT-hFVIII, and Ad-Apo-cFVIII.

Toxicity analysis of HC-Ad vectors.

AST (black bars) and ALT (gray bars) levels (A) in plasma from FVIIIKO-SCID mice injected intravenously with 5 × 109 IU Ad-AAT-cFVIII, Ad-AAT-hFVIII, and Ad-Apo-cFVIII. Alternatively, 5 × 109 IU Ad-AAT-cFVIII was injected intravenously into FVIIIKO mice. (A) Platelet counts (B) and IL-6 levels (C) in plasma from FVIIIKO-SCID mice intravenously injected with 5 × 109 IU Ad-AAT-cFVIII, Ad-AAT-hFVIII, and Ad-Apo-cFVIII.

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